Solid Tumours

A suite of SOPs by cancer type relating to sample collection for isolation of tumour-infiltrating lymphocytes (TILs)

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Collection of Tissues for Isolation of Tumour Infiltrating Lymphocytes – A Process Overview of SOPs

An overview of points to consider and SOPs required when establishing a new pathway for the collection of tissues to isolate tumour infiltrating lymphocytes (TIL). Relevant for both research and clinical tissue collection.
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Consenting Hepato-Pancreatico-Biliary (HBP) patients for Bio-bank SOP

SOP re: consenting Hepato-Pancreatico-Biliary (HBP) patients for biobank
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iMATCH Bio-banking Consent SOP

The process for consenting patient’s tissue to be stored in a biobank for use in medical research, relating to tumour infiltrating lymphocytes (TIL)
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iMATCH Clinical SOP Development

An overview of patient pathways relating to the collection of tissues to isolate tumour infiltrating lymphocytes (TIL).
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Procurement of cells or tissues as starting ATMP materials – eLearning Module

E-learning on the NHS e-learning platform e-learning for healthcare (registration required) giving the user an overview of the procedural requirements for the procurement of human tissues and cells but does not discuss in depth the consent and ethics requirements

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Receipt processing and release of fresh cells as starting material for manufacture

Form to complete when receiving, processing and releasing fresh cells for manufacturing
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SOP – Overview of Services in Greater Manchester

An overview of surgical sites and services in Greater Manchester, relating to the collection of tissues to isolate tumour infiltrating lymphocytes (TIL).
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SOP – Preparation and maintenance of tumour-infiltrating lymphocyte, cancer associated fibroblast and autologous tumour cultures (ovarian cancer)

The purpose of this document is to provide clear guidance on the procedures to be followed during the processing of ovarian tumour tissue to establish a) a tumour infiltrating lymphocyte culture; (b) an autologous tumour cell culture; (c) a cryopreserved aliquot of tumour culture digest; (d) subsequent cryopreservation of TIL and autologous tumour cultures for future assays.
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SOP – Tissue Collection from Neuro Patients

SOP re: tissue consent for Neurological patients relating to TIL therapy research/ treatment.
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SOP for patient recruitment for Breast Cancer tumour samples for adoptive T-Cell therapy

This SOP will describe the patient recruitment process for prospective breast tumour sample collection (for medical research relating to adoptive T-Cell Therapy)
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SOP- Generalised Tissue Collection where tissue microarchitecture must be preserved to protect the standard of care

This SOP provides clear guidance on the procedures to be followed during the acquisition of tissue for therapeutic purposes undertaken within the institute/trust.
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SOP- Generalised Tissue Collection where tissue, surplus to requirement, is available and be collected without effecting standard of care

This SOP provides the basis for the standardised collection of solid tumour and fluid samples from cancer patients undergoing surgical treatment, where there is excessive tumour tissue available which can be collected without effecting the normal standard of care.
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UK review and recommendations on cryopreservation of starting materials for ATMP

Cryopreservation is now integrated into the manufacturing workflow of approved ATMPs. However, a comprehensive end-to-end solution for large scale ATMP production is still under development. This document provides an overview of the current state of cryopreservation in ATMP workflows by: addressing where cryopreservation fits into the workflow, the rules and regulations, the major challenges of cryopreservation logistics; reviewing the effects of cryopreservation of starting materials on the final product safety and efficacy and how developing technologies are set to help optimize cryopreservation processes for scalable manufacturing.
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Worklist for Issue of frozen products for as starting material for manufacture

A checklist to follow to confirm all steps are appropriately carried out for cell therapy starting materials to be sent to manufacturer