The CAR T-Cell Therapy Clinical Journey Guide
Glossary
Leukapheresis
A procedure that involves removing blood from the body, delivering it to a machine that separates and collects white blood cells and then returning the remaining blood components to the body.
Long-term follow-up study (LTFU)
A study in which patients in a clinical trial are monitored for an extended period of time to learn about possible delayed side effects.
LTFU
Long-term Follow-Up (study)
Lumbar puncture (spinal tap)
A procedure that takes a sample of cerebrospinal fluid (liquid that surrounds the brain and spinal cord). This is done by inserting a needle between two vertebrae (bones in the spine).
Lymphocytes
White blood cells that play an important role in the immune system. There are three types: B cells, T cells and Natural Killer (NK) cells.
Lymphodepleting chemotherapy
Chemotherapy given before CAR-T cell infusion in order to decrease the number of white blood cells (including T cells) in the body. CAR T cells grow and expand better if there are not as many of the patient’s own T-cells present.
