The CAR T-Cell Therapy Clinical Journey Guide



A small tube inserted into a vessel, cavity or duct to allow flow of substances (usually fluids).


Chimeric Antigen Receptor


See Chimeric antigen receptor (CAR).


A thin tube used to deliver blood, fluids or medications into a vein.


An antigen, or “marker” found on the surface of B cells. See ‘antigens’.


The basic membrane-bound unit of life that composes all living things.

Chimeric antigen receptor (CAR)

A protein created in a laboratory that is designed to recognise an antigen (or marker) on cancer cells. When added to T cells, CARs give T cells (now called “CAR T cells”) the ability to identify and destroy cancer cells.

Chronic stressor

Stress resulting from repeated exposure to situations that lead to the release of stress hormones. This type of stress can cause wear and tear on your mind and body.

Clinical Research Team

A group of professionals involved in all aspects of running a clinical trial. Team members can include investigators, research nurses and coordinators, data managers, staff nurses and doctors. In some centres, team members may also serve as the healthcare providers for trial participants.

Clinical trial

Research that involves one or more human participants, carried out to learn if a treatment is safe and/or works.


Cytokine Release Syndrome

CT or CAT scan

Uses a group of X-rays taken at different angles around the body and a computer to create detailed cross-sectional images.

Cytokine Release Syndrome (CRS)

A common side effect of CAR T-cell therapy. CRS occurs when many cytokines are released by immune cells during immunotherapy. Some symptoms are nausea, fever, headache, rapid heartbeat, low blood pressure, rash and trouble breathing. CRS can be mild or moderate. CRS can feel like a very bad case of the flu, but in rare cases it can be severe or life-threatening.

Cytokine Storm

See Cytokine Release Syndrome.


Small proteins that regulate the immune system. Cytokines are released by certain immune system cells. They can stimulate the immune system to attack cancer and also cause the production of more cytokines.


Low blood cell counts, including red blood cells, white blood cells, and platelets.