The CAR T-Cell Therapy Clinical Journey Guide



Allo means “other”. Allogeneic means that the cells or tissue given to a patient come from someone other than the patient.


An X-ray image of blood vessels that uses a dye so that the blood vessels can be seen.


A substance used to prevent the formation of blood clots or break up existing blood clots.


An antigen is anything that can be “seen” by the immune system. There are many different types of antigens. In CAR T-cell therapy, antigens are a substance (or marker) on the outside of a cell that is recognised by the CAR T cell and ‘marks’ the cell for destruction. An example of an antigen (or marker) in CAR T-cell therapy is CD19, found on the outside of both normal and cancerous B cells.


The process of removing whole blood from a patient, processing the blood in a machine that separates out one component and then returning the remainder of the blood components to the patient. There are several kinds of apheresis procedures, each named after the component of blood that is extracted. When white blood cells are extracted, the process is called leukapheresis.


Indicates that a drug or therapy has been fully tested in clinical trials to ensure it is safe and effective and has been approved for use outside of a clinical trial by the MHRA.


Auto means “self”. Autologous means that the cells or tissue given to a patient come from that same individual.